Analyzing the role of extracellular matrix during nervous system development to advance new regenerative strategies
Teresa Caprile
Hernán Montecinos
摘要：Regeneration in the central nervous system (CNS) is limited, and CNS damage often leads to cognitive impairment or permanent functional motor and sensory loss. Impaired regenerative capacity is multifactorial and includes inflammation, loss of the bloodbrain barrier, and alteration in the extracellular matrix (ECM). One of the main problems is the formation of a glial scar and the production of inhibitory ECM, such as proteoglycans, that generates a physical and mechanical barrier, impeding axonal regrowth (Figure 1A).
机标关键词：system developmentcentral nervous systemextracellular matrixbloodbrain barrier
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 566-567 )