RhoA/ROCK activation in major pelvic ganglion mediates caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury
Michael Bell
Nikolai A. Sopko
Hotaka Matsui
Johanna L. Hannan
Trinity J. Bivalacqua
摘要：Severe erectile dysfunction (ED) remains a significant side effect among men following surgical intervention for treatment of clinically localized prostate cancer, despite development of nerve-sparing techniques (Weyne et al., 2015a; Sopko and Burnett, 2016). The type of axonal injury due to prostatectomy is a classic peripheral neuropathy with an acute inflammatory phase that leads to Wallerian degeneration of the canvernous nerve (CN), which can be followed by a regenerative phase characterized by enhanced neurotrophic factor activation and reduction in neuroinflammation (Weyne et al., 2015b).
机标关键词：nerve injuryWallerian degenerationsurgical interventionperipheral neuropathyerectile dysfunctionneurotrophic factorprostate cancerside effect
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 572-573 )