P2X7 receptor antagonism in amyotrophic lateral sclerosis
Ronald Sluyter
Rachael Bartlett
Diane Ly
Justin J.Yerbury
摘要：Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disorder characterized by the degeneration and subsequent loss of upper and lower motor neurons, resulting in reduced muscle function and paralysis (Mathis et al., 2017). Current therapies are limited to the oral administration of riluzole, which improves survival by only 3 months (Mathis et al., 2017).Thus, new thera-pies are urgently required to treat this neurodegenerative disor-der. Over the past decade, the intercellular signaling pathway in-volving extracellular adenosine triphosphate (ATP) activation of the P2X7 receptor channel has emerged as a potential therapeutic target in ALS (Volonte et al., 2016).
机标关键词：adenosine triphosphateoral administrationsignaling pathwaymotor neurons
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 749-750 )