Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
Ilknur Keskin
M.Yalcin Gunal
Nilufer Ayturk
Ulkan Kilic
Mehmet Ozansoy
Ertugrul Kilic
摘要：Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intra-peritoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes.These findings suggest that enoxaparin exhibits neuroprotective effect on cold-in-duced traumatic brain injury in a dose-dependent manner.
机标关键词：traumatic brain injuryneuroprotective effecttherapeutic effectcell apoptosis
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 761-764 )
英文信息