Curcuma longa L. extract improves the cortical neural connectivity during the aging process
Gonzalo Flores
摘要：Turmeric or Curcuma is a natural product that has anti-inflammatory, antioxidant and anti-apoptotic pharmacological properties. It can be used in the control of the aging process that involves oxidative stress, inflammation, and apoptosis. Aging is a physiological process that affects higher cortical and cognitive functions with a reduction in learning and memory, limited judgment and deficits in emotional control and social behavior. Moreover, aging is a major risk factor for the appearance of several disorders such as cerebrovascular disease, diabetes mellitus, and hypertension. At the brain level, the aging process alters the synaptic intercommunication by a reduction in the dendritic arbor as well as the number of the dendritic spine in the pyramidal neurons of the prefrontal cortex, hippocampus and basolateral amygdala, conse-quently reducing the size of these regions. The present review discusses the synaptic changes caused by the aging process and the neuroprotective role the Curcuma has through its anti-inflammatory, antioxidant and anti-apoptotic actions.
机标关键词：aging processcerebrovascular diseaselearning and memoryprefrontal cortexoxidative stresssocial behaviornatural productrisk factor
资助基金：This study was supported by grants from the VIEP-BUAP grant(FLAG-2017)ProDES(CA-BUAP-120)CONACYT grant (No. 252808)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 875-880 )
英文信息