Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair
Angelina Angelova
Borislav Angelov
摘要：Among the macromolecular drug targets in neurodegenerative disorders, the neurotrophin brain-derived neurotrophic factor (BDNF) and its high-affinity tropomyosin-related kinase receptor (TrkB) present strong interest for nanomedicine development aiming at neuronal and synaptic repair. Currently, BDNF is regarded as the neurotrophic factor of highest therapeutic significance. However, BDNF has delivery problems as a protein drug. The enhanced activation of the transcription factor CREB (cAMP response ele-ment-binding protein) has been evidenced to increase the BDNF gene expression and hence the production of endogenous BDNF. We assume that BDNF delivery by nanocarriers and mitochondrial protection may provide high potential for therapeutic amelioration of the neuroregenerative strategies. Beneficial therapeu-tic outcomes may be expected for synergistic dual or multi-drug action aiming at (i) neurotrophic protein regulation in the central and peripheral nervous systems, and (ii) diminishment of the production of reac-tive oxygen species (ROS) and the oxidative damage in mitochondria. Our research strategy is based on a nanoarchitectonics approach for the design of nanomedicine assemblies by hierarchical self-assembly. We explore nanoarchitectonics concepts in soft-matter nanotechnology towards preparation of biodegradable self-assembled lipid nanostructures for safe neuro-therapeutic applications of multi-target nanomedicines.
机标关键词：neurotrophic factorneurodegenerative disorderstranscription factoroxidative damagegene expressionoxygen speciesprotein drug
资助基金：AA is supported by CNRS. BA is supported by the Czech Science Foundation Grant GACR 17-00973S and the projects ELI - Extreme Light Infrastructure – phase 2(CZ.02.1.01/0.0/0.0/15_008/0000162)ELIBIO (CZ.02.1.01/0.0/0.0/15_003/0000447)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 886-889 )
英文信息