High-frequency and brief-pulse stimulation pulses terminate cortical electrical stimulation-induced afterdischarges
Zhi-wei Ren
Yong-jie Li
Tao Yu
Duan-yu Ni
Guo-jun Zhang
Wei Du
Yuan-yuan Piao
Xiao-xia Zhou
摘要：Brief-pulse stimulation at 50 Hz has been shown to terminate afterdischarges observed in epilepsy patients. However, the optimal pulse stimulation parameters for terminating cortical electrical stimulation-induced afterdischarges remain unclear. In the present study, we examined the effects of different brief-pulse stimulation frequencies (5, 50 and 100 Hz) on cortical electrical stimulation-induced after-discharges in 10 patients with refractory epilepsy. Results demonstrated that brief-pulse stimulation could terminate cortical electrical stimulation-induced afterdischarges in refractory epilepsy patients. In conclusion, (1) a brief-pulse stimulation was more effective when the afterdischarge did not extend to the surrounding brain area. (2) A higher brief-pulse stimulation frequency (especially 100 Hz) was more likely to terminate an afterdischarge. (3) A low current intensity of brief-pulse stimulation was more likely to terminate an afterdischarge.
机标关键词：refractory epilepsy
资助基金：the Capital Health Research and Development Special Funds of China, (No. 2016-1-2011)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 938-944 )
英文信息