Schwann cell development, maturation and regeneration: a focus on classic and emerging intracellular signaling pathways
Luca Franco Castelnovo
Veronica Bonalume
Simona Melif
Marinella Ballabio
Deborah Colleoni
Valerio Magnaghi
摘要：The development, maturation and regeneration of Schwann cells (SCs), the main glial cells of the periph-eral nervous system, require the coordinate and complementary interaction among several factors, signals and intracellular pathways. These regulatory molecules consist of integrins, neuregulins, growth factors, hormones, neurotransmitters, as well as entire intracellular pathways including protein-kinase A, C, Akt, Erk/MAPK, Hippo, mTOR,etc. For instance, Hippo pathway is overall involved in proliferation, apoptosis, regeneration and organ size control, being crucial in cancer proliferation process. In SCs, Hippo is linked to merlin and YAP/TAZ signaling and it seems to respond to mechanic/physical challenges. Recently, among factors regulating SCs, also the signaling intermediates Src tyrosine kinase and focal adhesion kinase (FAK) proved relevant for SC fate, participating in the regulation of adhesion, motility, migration andin vitro my-elination. In SCs, the factors Src and FAK are regulated by the neuroactive steroid allopregnanolone, thus corroborating the importance of this steroid in the control of SC maturation. In this review, we illustrate some old and novel signaling pathways modulating SC biology and functions during the different develop-mental, mature and regenerative states
机标关键词：focal adhesion kinasetyrosine kinasenervous systemSchwann cells
资助基金：Financial support by University of Milan, institutional funding "Pia(no di sostegno per la ricerca 2016 -Linea 2 Azione B", is gratefully acknowledged)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 1013-1023 )
英文信息