BDNF pro-peptide: a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing
Toshiyuki Mizui
Koji Ohira
Masami Kojima
摘要：Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and pro-domain. However, compared with the expression and function of bioactive mature domain, the biological role of the pro-domain is poorly understood. Unexpectedly, we found that the pro-domain (or pro-peptide) of brain-derived neurotrophic factor (BDNF), which is well-known neurotrophic factor in brain, has a potential ability to facilitate hippocampal long-term depression. Furthermore, a BDNF poly-morphism Val66Met, which substitute valine into methionine at 66 amino acid, impacted the biological activity of the BDNF pro-peptide. We lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.
机标关键词：neurotrophic factorbiological activityneural stem cellsgrowth factorsamino acid
资助基金： KAKENHI Grant-in-Aid for Scientific Research (17K07073 and 22500305)((Elucidation of neural network function in the brain) from the Ministry of Education, Culture, Sports, Science and Technology of Japan)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1024-1027 )
英文信息