RACK1 regulates neural development
Leah Kershner
Kristy Welshhans
摘要：Receptor for activated C kinase 1 (RACK1) is an evolutionarily conserved scaffolding protein within the tryptophan-aspartate (WD) repeat family of proteins. RACK1 can bind multiple signaling molecules con-currently, as well as stabilize and anchor proteins. RACK1 also plays an important role at focal adhesions, where it acts to regulate cell migration. In addition, RACK1 is a ribosomal binding protein and thus, reg-ulates translation. Despite these numerous functions, little is known about how RACK1 regulates nervous system development. Here, we review three studies that examine the role of RACK1 in neural development. In brief, these papers demonstrate that (1) RACK-1, theC. elegans homolog of mammalian RACK1, is re-quired for axon guidance; (2) RACK1 is required for neurite extension of neuronally differentiated rat PC12 cells; and (3) RACK1 is required for axon outgrowth of primary mouse cortical neurons. Thus, it is evident that RACK1 is critical for appropriate neural development in a wide range of species, and future discoveries could reveal whether RACK1 and its signaling partners are potential targets for treatment of neurodevelop-mental disorders or a therapeutic approach for axonal regeneration.
机标关键词：axonal regenerationsystem developmentbinding proteincell migrationrange of
资助基金：Research in the author's laboratory that is related to this review article is supported by a grant from NIH (NINDS)Research in the author's laboratory that is related to this review article is supported by a grant from NIH ( grant number R15NS098389 to KW)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1036-1039 )
英文信息