Neuroregeneration using in vivo cellular reprogramming
Tu Nguyen
Raymond Ching-Bong Wong
摘要：Cellular reprogramming is an innovative technology used to artifi-cially convert a mature cell type into a different cell type by molec-ular manipulation. The general concept of cellular reprogramming is to use master transcription factors to override the endogenous transcriptome profile of a given cell type with the transcriptome profile of the target cell type, thereby altering the cellular function and identity. One of the most well-known examples of cellular re-programming is the use of four transcription factors, octamer-bind-ing transcription factor 4 (Oct4), sex determining region Y-box 2 (Sox2),c-Myc, and Kruppel-like factor 4 (Klf4) to reprogram somatic cells into induced pluripotent stem cells, which led to the award of the Nobel Prize in physiology to Shinya Yamanaka and colleagues in 2012. Beyond induced pluripotency, cellular reprogramming has been used to convert one somatic cell type directly into another so-matic lineage, yielding promising results for thein vitro conversion of fibroblasts directly into neurons, oligodendrocytes, cardiomyo-cytes, muscle cells, blood progenitors and hepatocytes.
机标关键词：transcription factorssomatic cellstarget cellstem cells
资助基金：RCBW was supported by grants from the National Health and Medical Research Council(1084256)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1073-1074 )