Neural differentiation of human Wharton's jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats
Lei Zhang
Lin-mei Wang
Wei-wei Chen
Zhi Ma
Xiao Han
Cheng-ming Liu
Xiang Cheng
Wei Shi
Jing-jing Guo
Jian-bing Qin
Xiao-qing Yang
Guo-hua Jin
Xin-hua Zhang
摘要：Human Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs) have excellent proliferative ability, differentiation ability, low immu-nogenicity, and can be easily obtained. However, there are few studies on their application in the treatment of ischemic stroke, therefore their therapeutic effect requires further verification. In this study, hWJ-MSCs were transplanted into an ischemic stroke rat model via the tail vein 48 hours after transient middle cerebral artery occlusion. After 4 weeks, neurological functions of the rats implanted with hWJ-MSCs were significantly recovered. Furthermore, many hWJ-MSCs homed to the ischemic frontal cortex whereby they differentiated into neuron-like cells at this region. These results confirm that hWJ-MSCs transplanted into the ischemic stroke rat can differentiate into neu-ron-like cells to improve rat neurological function and behavior.
机标关键词：ischemic strokemiddle cerebral arterymesenchymal stem cellstherapeutic effectrat model
资助基金：This study was supported by the National Natural Science Foundation of China, (No. 31171038)the Natural Science Foundation of Jiangsu Province of China, (No. BK2011385)the "333" Program Funding of Jiangsu Province of China, (No. BRA2016450)the Training Program of Innovation and Entrepreneurship for Undergraduates of Nantong University of China, (No. 201510304033Z, 201610304053Z)the Training Program of Innovation and Entrepreneurship for Graduates of Nantong University of China, (No. YKC14050, YKC15046)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1103-1110 )
英文信息