Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system
Julia J. Segura-Uribe
Rodolfo Pinto-Almazán
Angélica Coyoy-Salgado
Claudia E. Fuentes-Venado
Christian Guerra-Araiza
摘要：Estrogen receptor modulators are compounds of interest because of their estrogenic agonistic/antagonis-tic effects and tissue specificity. These compounds have many clinical applications, particularly for breast cancer treatment and osteoporosis in postmenopausal women, as well as for the treatment of climacter-ic symptoms. Similar to estrogens, neuroprotective effects of estrogen receptor modulators have been described in different models. However, the mechanisms of action of these compounds in the central nervous system have not been fully described. We conducted a systematic search to investigate the effects of estrogen receptor modulators in the central nervous system, focusing on the modulation of cytoskeletal proteins. We found that raloxifene, tamoxifen, and tibolone modulate some cytoskeletal proteins such as tau, microtuble-associated protein 1 (MAP1), MAP2, neurofilament 38 (NF38) by different mechanisms of action and at different levels: neuronal microfilaments, intermediate filaments, and microtubule-associated proteins. Finally, we emphasize the importance of the study of these compounds in the treatment of neuro-degenerative diseases since they present the benefits of estrogens without their side effects.
机标关键词：central nervous systemcytoskeletal proteinsestrogen receptorpostmenopausal womentissue specificitybreast cancerside effects
资助基金：This study was supported by FIS/IMSS project (No. FIS/IMSS/PROT/G13/1216. CGA received Beca de Excelencia en Investigación by Fundación IMSS, ACS, JJSU received financial support from CIS/IMSS and CONACyT, RPA received financial support from USC-CONACYT Postdoctoral Scholars Program)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1231-1240 )
英文信息