Erythropoietin enhanced recovery after peripheral nerve injury
Max Modrak
Leigh Sundem
John Elfar
摘要：Peripheral nerve injuries are common disorders affecting the US population and represent a great economic and social burden. Acute injuries to peripheral nerves are most often due to an acute trauma or iatrogenic injury, with the resultant neurological deficit dependent on the injury type and severity. Clinical manifestations include a variable degree of motor and/or sensory deficits, with complete loss of motor function and intractable neuropathic pain seen in severe injuries. Current treatment strategies are limited and are lacking in their ability to improve outcomes. Surgical interven-tion is reserved for the most severe nerve injuries, leaving the mild to moderate injuries as the most challenging to treat clinically due to the lack of effective therapeutic options. In some cases, return of functional ability may occur spontaneously over time. Conversely, neurologic deficits may persist long-term with an incomplete res-toration of function; complete recovery, if it occurs at all, can take months or even years. Even with surgical intervention, outcomes are variable and return to normal function is achieved in less than 50% of patients (Pfister et al., 2011).
机标关键词：surgical interventionneurological deficitperipheral nervesneuropathic painnormal functionmotor function
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1268-1269 )