A role for lipids as agents to alleviate stroke damage: the neuroprotective effect of 2-hydroxy arachidonic acid
Irene F. Ugidos
Diego Pérez-Rodríguez
Arsenio Fernández-López
摘要：Cerebrovascular accident (CVA) or stroke is one of the world's leading causes of death and permanent disability.The high social and medical costs associated with this pa-thology mean there is an urgent need to find effective ther-apies. Occlusion of the middle cerebral artery (MCAO), mainly by clots, is the origin of most CVAs in humans.The vessel occlusion (ischemic stroke) presents as a region with a significant reduction in blood flow, known as the ischemic core. This is surrounded by a region called the penumbra, where the blood flow is only partially reduced and neurons can still survive if they are able to recover their homeostatic balance (Durukan and Tatlisumak, 2007). Both the ischemic core and penumbra can be re-produced in experimental transient MCAO (tMCAO), a focal cerebral ischemia model widely used to analyze the neuroprotective role of molecules with the potential to be-come therapeutic drugs.
机标关键词：arachidonic acidfocal cerebral ischemiamiddle cerebral arteryblood flowpartially reducedmedical coststhe world
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1273-1275 )