Extract of Ginkgo biloba promotes neuronal regeneration in the hippocampus after exposure to acrylamide
Wei-ling Huang
Yu-xin Ma
Yu-bao Fan
Sheng-min Lai
Hong-qing Liu
Jing Liu
Li Luo
Guo-ying Li
Su-min Tian
摘要：Previous studies have demonstrated a neuroprotective effect of extract of Ginkgo biloba against neuronal damage, but have mainly focused on antioxidation of extract of Ginkgo biloba. To date, limited studies have determined whether extrasct of Ginkgo biloba has a protective effect on neuronal damage. In the present study, acrylamide and 30, 60, and 120 mg/kg extract of Ginkgo biloba were administered for 4 weeks by gavage to establish mouse models. Our results showed that 30, 60, and 120 mg/kg extract of Ginkgo biloba effectively alleviated the abnormal gait of poisoned mice, and up-regulated protein expression levels of doublecortin (DCX), brain-derived neurotrophic factor, and growth associated protein-43 (GAP-43) in the hippocampus. Simultaneously, DCX- and GAP-43-immunoreactive cells increased.These findings suggest that extract of Ginkgo biloba can mitigate neurotoxicity induced by acrylamide, and thereby promote neuronal re-generation in the hippocampus of acrylamide-treated mice.
机标关键词：Ginkgo bilobaneuroprotective effectneurotrophic factorprotein expression
资助基金：This study was supported by the Natural Science Foundation of Guangdong Province of China, (No. 2014A030310455)the Pearl River S&T Nova Program Foundation of Guangzhou City of China, (No. 201710010002)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1287-1293 )
英文信息