Promises and pitfalls of immune-based strategies for Huntington's disease
Gabriela Delevati Colpo
Erin Furr Stimming
Natalia Pessoa Rocha
Antonio Lucio Teixeira
摘要：Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selec-tive loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin. Several studies have suggested that inflammation is an important feature of HD and it is already observed in the early stages of the disease. Recently, new molecules presenting anti-inflammatory and/or immunomodulatory have been investigated for HD. The objective of this review is to discuss the data obtained so far on the immune-based therapeutic strategies for HD.
机标关键词：motor dysfunction
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1422-1425 )
英文信息