Extracellular signal-regulated kinase, substance P and neurokinin-1 are involved in the analgesic mechanism of herb-partitioned moxibustion
Zhi-yuan Li
Yan-ting Yang
Jue Hong
Dan Zhang
Xiao-fei Huang
Li-jie Wu
Huan-gan Wu
Zheng Shi
Jie Liu
Yi Zhu
Xiao-peng Ma
摘要：Herb-partitioned moxibustion can effectively mitigate visceral pain, a major symptom in inflammatory bowel disease, but the analgesic mechanism is still unclear. Moreover, extracellular signal-regulated kinase, substance P, and neurokinin-1 are involved in formation of central hyperalgesia. Thus, we postulated that the analgesic effect of herb-partitioned moxibustion may be associated with these factors. Accordingly, in this study, we established an inflammatory bowel disease visceral pain model in rat by enema with a mixed solution of 5%trinitrobenzenesulfonic acid and 50% ethanol. BilateralTianshu (ST25) andQihai (CV6) points were selected for herb-partitioned moxi-bustion. Our results showed that herb-partitioned moxibustion improved visceral pain and down-regulated extracellular signal-regulated kinase, substance P, and neurokinin-1 protein and mRNA expression in dorsal root ganglia. These results indicate that down-regulation of extracellular signal-regulated kinase, substance P, and neurokinin-1 protein and mRNA may be a central mechanism for the analgesic effect of herb-partitioned moxibustion.
机标关键词：inflammatory bowel diseasevisceral painanalgesic effectdorsal root gangliamRNA expression
资助基金：This study was supported by the National Natural Science Foundation of China, (No. 81273843, 81674073)the Project Fund of Shanghai Municipal Commission of Health and Family Planning of China, (No. 20144Y0153, 2017BR047)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1472-1478 )
英文信息