Conductive polymer scaffolds to improve neural recovery
Shang Song
Paul M. George
摘要：Injuries to the nervous system manifest in various forms ranging from stroke to trauma (i.e., motor vehicle acci-dents, combats) to diabetic neuropathy as well as many other neurological diseases. Nerve regeneration remains a complex biological process that is challenging to ad-dress clinically. There is no effective medical treatment for central nervous system repair. For a peripheral inju-ry, the current gold standard for treating critically-sized neve defects (> 10 mm) is to use autologous nerve grafts, which have only shown 80% functional recovery. These grafts have significant drawbacks including the availabil-ity of donor source, size of donor nerve, and morbidity and scarring occurring at the donor site. Nerve tissue en-gineering provides a new alternative to neural recovery. Specifically, biomaterials integrate natural or synthetic biomimetic materials and biological systems to facilitate regeneration of diseased tissues and organs. Conductive polymers in particular provide a platform to manipulate cell behavior through electrical stimulation in addition to the existing biophysical and biochemical cues presented in the microenvironment (George et al., 2017). The abil-ity to fabricate advanced materials allows us to re-create physiologic conditions that more dynamically interact with the nervous system and improve neural repair.
机标关键词：central nervous systemelectrical stimulationbiomimetic materialsdiabetic neuropathybiological systemsbiological processadvanced materialsmedical treatment
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1976-1978 )