Implications of periostin in the development of subarachnoid hemorrhage-induced brain injuries
Hirofumi Nishikawa
Hidenori Suzuki
摘要：Target of research in subarachnoid hemorrhage (SAH): The outcome of aneurysmal SAH remains poor despite advances in the diagnosis and treatment. Although many factors related to patients, aneurysms, and institutions, as well as physiological parameters and medical complications were reported as prog-nostic factors, the most important determinant of poor outcome is the devastating effect of acute SAH on the brain causing early brain injury (EBI) (Suzuki, 2015). In acute SAH, the brain faces numerous deleterious conditions, including transient global ischemia induced by elevated intracranial pressure, mechanical stress, intracerebral hemorrhage due to an aneurysmal rupture, acute hydrocephalus, early cerebral infarction, seizure, direct effects of subarachnoid blood, and iatrogenic causes. EBI is a concept to explain acute pathophysiological events that occur in brain before onset of cerebral vasospasm within the first 72 hours of SAH, and consists of the pathophysiological mecha-nisms responsible for any type of brain insults other than iatro-genic brain injury (Suzuki, 2015). Recent experimental studies emphasize that EBI may be more important than cerebral vaso-spasm, a classically important determinant of poor outcome, in post-SAH outcome.
机标关键词：physiological parametersbrain injurysubarachnoid hemorrhagediagnosis and treatmentintracranial pressureexperimental studiescerebral infarctioncerebral vasospasm
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1982-1984 )