The Drosophila adult neuromuscular junction as a model for unravelling amyloid peptide influence on synapse dynamics
Bego?a López-Arias
Ignacio Monedero
Enrique Turiégano
Laura Torroja
摘要：Amyloid peptide (Aβ) oligomers are considered one of the pri-mary causal factors for the synaptic loss characteristic of Alzhei-mer's disease (AD) (Karran and De Strooper, 2016). However, Aβ is generated in normal brains and accumulates at synaptic sites, which raises the question whether Aβ plays a physiological role in synapses. This unresolved issue is especially relevant in view of the recent AD therapeutic strategies aimed at blocking or reduc-ing Aβ production. Here, we justify the use of the Drosophila adult neuromuscular junction (NMJ) as a model to address this question, describe our recent results that indicate that Aβ regulates synapse dynamics, and suggest future approaches to understand Aβ synap-tic function.
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论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1987-1989 )