Electroacupuncture improves neurovascular unit reconstruction by promoting collateral circulation and angiogenesis
Lei Shi
Hong-mei Cao
Ying Li
Shi-xin Xu
Yan Zhang
Yang Zhang
Zhe-feng Jin
摘要：Acupuncture at Shuigou (GV26) shows good clinical efficacy for treating stroke, but its mechanism remains poorly understood. In this study, a cerebral infarction model of ischemia/reperfusion injury received electroacupuncture at GV26 (15 Hz and 1 mA, continuous wave [biphasic pulses], for 5 minutes). Electroacupuncture effectively promoted regional cerebral blood flow on the infarct and non-infarct sides, increased infarct lesions, lectin, and number of blood vessels, upregulated von Willebrand factor and cell proliferation marker Ki67 expression, and diminished neurological severity score. These findings confirm that electroacupuncture at GV26 promotes establishment of collateral circulation and angiogenesis, and improves neurological function.
机标关键词：von Willebrand factorcerebral infarctioncerebral blood flowcell proliferationclinical efficacycirculation andblood vessels
资助基金：the National Natural Science Foundation of China, (No. 81303021)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 2000-2006 )
英文信息