Neural computational modeling reveals a major role of corticospinal gating of central oscillations in the generation of essential tremor
Hong-en Qu
Chuanxin M. Niu
Si Li
Man-zhao Hao
Zi-xiang Hu
Qing Xie
Ning Lan
摘要：Essential tremor, also referred to as familial tremor, is an autosomal dominant genetic disease and the most common movement disorder. It typically involves a postural and motor tremor of the hands, head or other part of the body. Essential tremor is driven by a central oscil-lation signal in the brain. However, the corticospinal mechanisms involved in the generation of essential tremor are unclear. Therefore, in this study, we used a neural computational model that includes both monosynaptic and multisynaptic corticospinal pathways interacting with a propriospinal neuronal network. A virtual arm model is driven by the central oscillation signal to simulate tremor activity behavior. Cortical descending commands are classified as alpha or gamma through monosynaptic or multisynaptic corticospinal pathways, which converge respectively on alpha or gamma motoneurons in the spinal cord. Several scenarios are evaluated based on the central oscillation signal passing down to the spinal motoneurons via each descending pathway. The simulated behaviors are compared with clinical essential tremor characteristics to identify the corticospinal pathways responsible for transmitting the central oscillation signal. A propriospinal neuron with strong cortical inhibition performs a gating function in the generation of essential tremor. Our results indicate that the pro-priospinal neuronal network is essential for relaying the central oscillation signal and the production of essential tremor.
机标关键词：computational modelautosomal dominantactivity behaviorgenetic diseasespinal cord
资助基金：This work was supported in part by the National Natural Science Foundation of China, (No. 61361160415, 81271684, 81501570)the Medicine-Engineering Interdisciplinary Research Grant from Shanghai Jiao Tong University in China, (No. YG2014ZD09)a grant from the Youth Eastern Scholar Program at Shanghai In-stitutions of Higher Learning in China, (No. QD2015007)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 2035-2044 )
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