Neuroprotective mechanisms of rutin for spinal cord injury through anti-oxidation and anti-inflammation and inhibition of p38 mitogen activated protein kinase pathway
Hong-liang Song
Xiang Zhang
Wen-zhao Wang
Rong-han Liu
Kai Zhao
Ming-yuan Liu
Wei-ming Gong
Bin Ning
摘要：Rutin has anti-inflammatory,antioxidant,anti-viral,anti-tumor and immune regulatory effects.However,the neuroprotective effects of rutin in spinal cord injury are unknown.The p38 mitogen activated protein kinase (p38 MAPK) pathway is the most important member of the MAPK family that controls inflammation.We assumed that the mechanism of rutin in the repair of spinal cord injury is associated with the inhibition of p38 MAPK pathway.Allen's method was used to establish a rat model of spinal cord injury.The rat model was intraperitoneally injected with rutin (30 mg/kg) for 3 days.After treatment with rutin,Basso,Beattie and Bresnahan locomotor function scores increased.Water content,tumor necrosis factor alpha,interleukin 1 beta,and interleukin 6 levels,p38 MAPK protein expression and caspase-3 and-9 activities in T8-9 spinal cord decreased.Oxidative stress related markers superoxide dismutase and glutathione peroxidase levels increased in peripheral blood.Rutin exerts neuroprotective effect through anti-oxidation,anti-inflammation,anti-apoptosis and inhibition of p38 MAPK pathway.
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资助基金：This work was supported in part by grants from the Young Scientists Awards Foundation of Shandong Province of China,(No.BS2013YY049)the China Postdoctoral Science Foundation,No.2012M511036.The study protocol was approved by the Animal Ethics Committee of Jinan Central Hospital Affiliated to Shandong University of China (2014-30)The experimental procedure followed the United States National Institutes of Health Guide for the Car(NIH Publication 85-23)The experimental procedure followed the United States National Institutes of Health Guide for the Car(revised 1985)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 128-134 )
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