Cerebral ischemia and neuroregeneration
Reggie H. C. Lee
Michelle H. H. Lee
Celeste Y. C. Wu
Alexandre Couto e Silva
Harlee E. Possoit
Tsung-Han Hsieh
Alireza Minagar
Hung Wen Lin
摘要：Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics (i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies (i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypother-mia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia.
机标关键词：
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 373-385 )
英文信息