Axotomy induces damage to glial cells remote from the transection site in the peripheral nervous system
Anatoly B. Uzdensky
摘要：Traumatic cerebral or spinal cord injury induced by military, traffic, and sports accidents, falls or environmental and anthropogenic ca-tastrophes are among main causes of people mortality and disabili-ty, especially in young and middle age men (Kobeissy, 2015). Axon transection, or axotomy, occurs in wounds and during surgery. Central neurons do not regenerate and die, but in the peripheral nervous system 25–30% of axotomized motor or sensory neurons survive and can regenerate and restore lost connections to their target cells. In order to treat the consequences of nerve injury, the balance between neurodegeneration and neuroprotection processes should be rapidly shifted to neuron survival. Unfortunately, reliable neuroprotective medications with proven efficiency are not found yet. So, comprehensive and deep study of molecular processes that occur after axon transection is required.
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论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 639-640 )