Neuromodulator interactions and spinal cord injury in lamprey
David Parker
omas J. McClelland
摘要：Neuromodulation is mediated by neurotransmitters that typically act on G-protein-coupled receptors. It can confer behavioural flexibility by mod-ifying the functional properties of anatomically hard-wired neural circuits. Single neuromodulators generally have divergent cellular and synaptic effects (Harris-Warrick and Johnson, 2010), and different modulators, of which there are many in even simpler systems, can interact by converging onto the same effectors. These interactions can generate synergistic, antag-onistic, or novel effects (see Harris-Warrick and Johnson, 2010). Further modulator complexity is offered by the potential for concentration, time, and state-dependent influences (see Parker, 2015 and references therein). All of these effects can make neuromodulation highly flexible, making it difficult to predict or explain the functional effects resulting from the tar-geting of even a single modulatory system. As many clinically used drugs target G-protein-coupled receptors, being able to explain and predict these effects is important.
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论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 643-644 )