Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases
Aline Freyssin
Guylène Page
Bernard Fauconneau
Agnès Rioux Bilan
摘要：Alzheimer's and Parkinson's diseases are the most common neurodegenerative diseases.They are characterized by protein aggregates and so can be considered as prion-like disease.The major components of these deposits are amyloid peptide and tau for Alzheimer's disease,α-synuclein and synphilin-1 for Parkinson's disease.Drugs currently proposed to treat these pathologies do not prevent neurodegenerative processes and are mainly symptomatic therapies.Molecules inducing inhibition of aggregation or disaggregation of these proteins could have beneficial effects,especially if they have other beneficial effects for these diseases.Thus,several natural polyphenols,which have antioxidative,anti-inflammatory and neuroprotective properties,have been largely studied,for their effects on protein aggregates found in these diseases,notably in vitro.In this article,we propose to review the significant papers concerning the role of polyphenols on aggregation and disaggregation of amyloid peptide,tau,α-synuclein,synphilin-1,suggesting that these compounds could be useful in the treatments in Alzheimer's and Parkinson's diseases.
机标关键词：
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 955-961 )
英文信息