Potential utility of aldose reductase-deficient Schwann cells IKARS1 for the study of axonal degeneration and regeneration
Naoko Niimi
Kazunori Sango
摘要：Diabetic peripheral neuropathy (DPN) is one of the most common and intractable complications of diabetes mellitus.Its irritating symptoms,such as paresthesia,hyperalgesia and allodynia,can be causes of insomnia and depression;whereas its progression to more advanced stages can result in serious consequences,such as lower limb amputations and lethal arrhythmias,The pathogenesis of DPN remains largely unknown,but long-term exposure to hyperglycemia is likely to play a major role in metabolic and vascular abnormalities in the peripheral nervous system (PNS).In the PNS,blood glucose is transported into the cells in an insulin-independent manner.
机标关键词：
资助基金：25430056)((grant number)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 979-980 )