The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration: new pharmacological concepts for old and new drugs
Solomon Habtemariam
摘要：Neurotrophins:Neurotrophins are peptides or proteins that are known to regulate neuronal viability,development,and function.Beyond synaptic plasticity,neurotrophins protect neurons from apoptosis and also promote neurogenesis to recover neuronal deficit even in adulthood.For various reasons that we have highlighted previously (Habtemariam,2016a),neuronal cells in the brain are highly susceptible to oxidative stress and hence efficient cell survival mechanisms must be maintained at all times.Many age-related and other neurodegenerative diseases (NDs) in the brain are also associated with excessive oxidative damage resulting from either high production of reactive oxygen species generated by neurotoxic agents (e.g.,amyloid beta (Aβ)) or suppressed level of antioxidant defenses.
机标关键词：
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 983-984 )