What can computational modeling offer for studying the Ca2+ dysregulation in Alzheimer's disease: current research and future directions
Jingyi Liang
Don Kulasiri
摘要：Ca2+ dysregulation is an early event observed in Alzheimer's disease (AD) patients preceding the presence of its clinical symptoms.Dysregulation of neuronal Ca2+ will cause synaptic loss and neuronal death,eventually leading to memory impairments and cognitive decline.Treatments targeting Ca2+ signaling pathways are potential therapeutic strategies against AD.The complicated interactions make it challenging and expensive to study the underlying mecha nisms as to how Ca2+ signaling contributes to the pathogenesis of AD.Computational modeling offers new opportunities to study the signaling pathway and test proposed mechanisms.In this mini-rewew,we present some comlputational approaches that have been used to study Ca2+ dysregulation of AD by simulating Ca2+ signaling at various levels.We also pointed out the future directions that computational modeling can be done in studying the Ca2+ dysregulation in AD.
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论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1156-1158 )
英文信息