Vascular endothelial growth factor: an essential neurotrophic factor for motoneurons?
Paula M.Calvo
Angel M.Pastor
Rosa R.de la Cruz
摘要：Vascular endothelial growth factor (VEGF),an angiogenic factor with neuroprotective effects:The VEGF was initially characterized by its vasculogenic and angiogenic activities and its capacity to promote vascular permeability (Yancopoulos et al.,2000).VEGF is also known as VEGF-A and is the prototype member of a related group of five trophic factors,VEGF-B,VEGF-C,VEGF-D and placental growth factor (PlGF;Lange et al.,2016).Interestingly,VEGF-B shares a high degree of homology with VEGF but,in contrast to VEGF,has low angiogenic activity and is not pro-inflammatory.VEGF-A binds to two tyrosine quinase receptors,named VEGFR-1 and VEGFR-2,and also to the coreceptor neuropilin-1.By contrast,VEGF-B only binds to the tyrosine kinase receptor VEGFR-1 and also to the coreceptor neuropilin-1 (Lange et al.,2016).
机标关键词：
资助基金：BFU2015-64515-P)((Grant reference)PMC was a scholar of MEC (BES-2016-077912)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1181-1182 )