Bone morphogenetic protein signaling: a promising target for white matter protection in perinatal brain injury
Jill Chang
Robert W.Dettman
Maria L.V.Dizon
摘要：Prematurely born newborns,as well as those born at term,may suffer from several types of brain injury including hypoxic-ischemic injury,intracranial hemorrhage,both intraventricular and parenchymal,and injury that is the consequence of intrauterine growth restriction (IUGR).Injury of all types can impact the motor and cognitive abilities of survivors.The mechanisms leading to disability are not completely understood.Here we discuss the role of the bone morphogenetic protein (BMP) signaling pathway in newborn brain injury.We review the evidence that the BMP signaling pathway is activated in various injury types and discuss the downstream effects of its activation and possible interventions to curtail the effects of this pathway's activation.In addition,we identify interactions with other signaling pathways important in neurodevelopment.
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论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1183-1184 )