Neurodegenerative diseases are a function of matrix breakdown: how to rebuild extracellular matrix and intracellular matrix
Greg Maguire
摘要：Matrix within cells,the cytoskeleton,and that which surrounds cells,the extracellular matrix (ECM),are connected to one another through a number of receptors including those in primary cilia,serving as an important chemical and physical signaling system:Mechanical forces generated through the matrix play a critical role in determining the form and function of tissues (Hughes et al.,2018).Such forces,even in adult tissues,will be important given that breakdown of the ECM in adults may lead to the tissue changing from an adult phenotype to one of primordial or embryonic (Bhat and Bissell,2014).As an example,chemical and mechanical signaling from the microenvironment and ECM to the cell can be so powerful as to change cellular phenotype from one of cancer to a normal somatic form (Bhat and Bissell,2014).Even in development and inheritance,the matrix is important for what embryos receive from egg and sperm upon fertilization.Centrioles,the matrix structures responsible for cell division,are given by the paternal gamete.In the oocytes,the matemal gametes,the centriole is lost through desolvation.Thus,paternal matrix inheritance through the centriole structure is another important example of mechanism of heredity beyond the genome that may have consequences to neural dysfunction.
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论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1185-1186 )