Brain repair for Parkinson's disease: is the answer in the matrix?
Niamh Moriarty
Eilís Dowd
摘要：Two hundred years after James Parkinson first described the cardinal motor symptoms of the disorder that would later bear his name,there is still an irrefutable need for a therapy that targets the underlying pathophysiology of the disease and not solely its symptoms.Parkin son's disease (PD) is classically characterised by Lewy body formation and a relatively selective degeneration of nigrostriatal dopaminergic neurons (Schapira and Jenner,2011).The loss of dopaminergic neurons from the substantia nigra pars compacta causes a consequential depletion of the neurotransmitter dopamine from the striatum,and it is this loss that causes the motor symptoms experienced by patients.
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资助基金：Our research in this field is supported by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2015)under the Marie Sklodowska-Curie Innovative Training Networks and Grant Agreement No.676408,Science Foundation Ireland(11/RFP/NES/3183)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1187-1188 )