Lateral olfactory tract usher substance (LOTUS) protein, an endogenous Nogo receptor antagonist, converts a non-permissive to permissive brain environment for axonal regrowth
Tomoko Hirokawa
Kohtaro Takei
摘要：It is well known that primates,including humans,hardly re cover motor function after spinal cord injury (SCI) when compared with non-primate mammals such as rodents.This limited functional recovery is in part due to a non-permissive environment of the central nervous system (CNS) inhibiting axonal regrowth.This inhibitory environment for axonal regrowth is mainly caused by interaction of axon growth inhibitors with their common receptor,Nogo receptor-1 (NgR1).Axon regrowth inhibitors such as Nogo proteins,myelin associated glycoprotein (MAG),oligodendrocyte myelin glycoprotein (OMgp) and B lymphocyte stimulator (BLyS) are derived from glial cells in damaged brain.
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论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1193-1194 )