Gamma-aminobutyric acid A receptors in Alzheimer's disease:highly localized remodeling of a complex and diverse signaling pathway
Andrea Kwakowsky
Beatriz Calvo-Flores Guzmán
Karan Govindpani
Henry J.Waldvogel
Richard L.Faull
摘要：Alzheimer's disease (AD),thepredominant form of dementia,is a chronic,incurable neurodegenerative disorder presenting with symptoms including progressive memory loss and disturbed emotional state.It has been estimated that dementia affects over 47 million people worldwide (Prince et al.,2015),and with 60-80％ of cases attributable to AD.The primary pathological hallmarks of AD are neuronal death,the deposition of insoluble amyloid-beta (Aβ) plaques,the accumulation of hyperphosphorylated tau neurofibrillary tangles (NFTs),and the widespread dysregulation of neurotransmitter signaling (Francis,2005;Vinters,2015).
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论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1362-1363 )