Nanometer ultrastructural brain damage following low intensity primary blast wave exposure
Hailong Song
Landry M.Konan
Jiankun Cui
Catherine E.Johnson
Graham K.Hubler
Ralph G.DePalma
Zezong Gu
摘要：Blast-induced mild traumatic brain injury (mTBI) is of particular concern among military personnel due to exposure to blast energy during military training and combat.The impact of primary low-intensity blast mediated pathophysiology upon later neurobehavioral disorders has been controversial.Developing a military preclinical blast model to simulate the pathophysiology of human blast injury is an important first step.This article provides an overview of primary blast effects and perspectives of our recent studies demonstrating ultrastructural changes in the brain and behavioral disorders resulting from open-field blast exposures up to 46.6 kPa using a murine model.The model is scalable and permits exposure to varying magnitudes of primary blast injuries by placing animals at different distances from the blast center or by changing the amount of C4 charge.We here review the implications and future applications and directions of using this animal model to uncover the underlying mechanisms related to primary blast injury.Overall,these studies offer the prospect of enhanced understanding of the pathogenesis of primary low-intensity blast-induced TBI and insights for prevention,diagnosis and treatment of blast induced TBI,particularly mTBI/concussion related to current combat exposures.
机标关键词：
资助基金：This publication was made possible by funding from the DoD Congressionally Directed Medical Research Programs (CDMRP) for the Peer Reviewed Alzheimer's Research Program Convergence Science Research Award(PRARP-CSRA)This publication was made possible by funding from the DoD Congressionally Directed Medical Research Programs (AZ140109)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1516-1519 )
英文信息