Schwann cell Myc-interacting zinc-finger protein 1 without pox virus and zinc finger: epigenetic implications in a peripheral neuropathy
David Fuhrmann
Hans-Peter Els(a)sser
摘要：Functionality of adult peripheral nerves essentially relies on differentiation of Schwann cells during postnatal development,as well as fine-tuned re-and transdifferentiation in response to peripheral nerve injury.Epigenetic histone modifications play a major role during the differentiation of embryonic stem cells and diverse organ specific progenitor cells,yet only little is known about the epigenetic regulation of Schwa nn cells.Just recently,Fuhrmann et al.reported how the transcription factor Myc-interacting zinc-finger protein 1 (Miz1) might contribute to Schwann cell differentiation through repression of the histone demethylase Kdm8.Here,we discuss the potential novel role of Miz1 in Schwann cell differentiation and give a short overview about previously reported histone modifications underlying peripheral nerve development and response to injury.
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资助基金：Deutsche Forschungsgemeinschaft (DFG grant EL125/6-1)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1534-1537 )
英文信息