The emerging epigenetics of PARK7 and its implication in neurodegenerative disease
George D.Vavougios
Sotirios G.Zarogiannis
摘要：PARK7/DJ-1 is a multifunctional protein that acts as a regulator in stress responsive cascades.Since its original discovery as a novel oncogene,DJ-1 was further implicated in the correspondingly dubbed PARK7 autosomal recessive early onset Parkinson's Disease variant,expanding the spectrum of its pathophysiology to neurodegenerative disease.DJ-1's physiological roles have correspondingly expanded in the literature,effectively revealing an almost ubiquitous presence in cellular compartments and tissues.DJ-1's functions mediate a diverse armamentarium of cytoprotective effects such as RNA binding,SUMOylation,androgen receptor binding,and regulation of mitochondrial dynamics as well as a recently discovered deglycase activity (Richarme et al.,2015).
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论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1542-1543 )