A radical scavenger edaravone and oligodendrocyte protection/ regeneration
Hajime Takase
Josephine Lok
Ken Arai
摘要：Cerebral white matter is vulnerable to oxidative stress:Oxidative stress is one of the major harmful conditions for the central nervous system (CNS).Oxidative stress is a state from an imbalance between free radical production and their removal by antioxidants,resulting in an excessive amount of reactive oxygen species (ROS) in cells and tissues.ROS causes call damage due to oxidation of cellular components,including DNAs,proteins,and lipids.During physiological conditions,small amounts of ROS are generated in the process of normal biological activity,and ROS at physiological levels play important roles in maintaining cellular homeostasis (Chen et al.,2018).However,during pathological conditions,ROS levels are increased and excessive ROS can lead to deleterious effects on many kinds of cells.
机标关键词：
资助基金：Supported in part by National Institutes of Health and the Rotary Foundation Global Scholarship Grants (GG1759314)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1550-1551 )