Melatonin for the treatment of spinal cord injury
Yan Zhang
Wen-Xiu Zhang
Yan-Jun Zhang
Ya-Dong Liu
Zong-Jian Liu
Qi-Chao Wu
Yun Guan
Xue-Ming Chen
摘要：Spinal cord injury (SCI) from trauma or disease severely impairs sensory and motor function. Neurore-habilitation after SCI is a complex medical process that focuses on improving neurologic function and repairing damaged connections in the central nervous system. An increasing number of preclinical studies suggest that melatonin may be useful for the treatment of SCI. Melatonin is an indolamine that is primarily secreted by the pineal gland and known to be regulated by photoperiodicity. However, it is also a versatile hormone with antioxidative, antiapoptotic, neuroprotective, and anti-inflammatory properties. Here, we review the neuroprotective properties of melatonin and the potential mechanisms by which it might be beneficial in the treatment of SCI. We also describe therapies that combine melatonin with exercise, oxy-tetracycline, and dexamethasone to attenuate the secondary injury after SCI and limit potential side effects. Finally, we discuss how injury at different spinal levels may differentially affect the secretion of melatonin.
机标关键词：
资助基金：the National Natural Science Foundation of China,(No.8167116)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1685-1692 )
英文信息