Cognitive impairment after traumatic brain injury is associated with reduced long-term depression of excitatory postsynaptic potential in the rat hippocampal dentate gyrus
Bao-Liang Zhang
Yue-Shan Fan
Ji-Wei Wang
Zi-Wei Zhou
Yin-Gang Wu
Meng-Chen Yang
Dong-Dong Sun
Jian-Ning Zhang
摘要：Traumatic brain injury can cause loss of neuronal tissue, remote symptomatic epilepsy, and cognitive deficits. However, the mechanismsunderlying the effects of traumatic brain injury are not yet clear. Hippocampal excitability is strongly correlated with cognitive dysfunctionand remote symptomatic epilepsy. In this study, we examined the relationship between traumatic brain injury-induced neuronal loss andsubsequent hippocampal regional excitability. We used hydraulic percussion to generate a rat model of traumatic brain injury. At 7 daysafter injury, the mean modified neurological severity score was 9.5, suggesting that the neurological function of the rats was remarkablyimpaired. Electrophysiology and immunocytochemical staining revealed increases in the slope of excitatory postsynaptic potentials andlong-term depression (indicating weakened long-term inhibition), and the numbers of cholecystokinin and parvalbumin immunoreactivecells were clearly reduced in the rat hippocampal dentate gyrus. These results indicate that interneuronal loss and changes in excitabilityoccurred in the hippocampal dentate gyrus. Thus, traumatic brain injury-induced loss of interneurons appears to be associated with reducedlong-term depression in the hippocampal dentate gyrus.
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资助基金：This study was supported by the National Natural Science Foundation of China,(No.81330029,81501057)the Natural Science Foundation of Tianjin of China,(No.17JCQNJC12000)the Tianjin Medical University General Hospital Funding in China,(No.ZYYFY2016014)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1753-1758 )
英文信息