Tissue inhibitors of metalloproteases strike a nerve
Veronica I. Shubayev
Alex Y. Strongin
摘要：Signals of touch, pressure, pain, temperature, position, and vibration are transmitted from the peripheral nervous sys-tem (PNS) to the dorsal horn of the segmental spinal cord via pseudounipolar dorsal root ganglia (DRG) neurons. Sensory information gathering relies on functional integrity of DRG neurons and can be interrupted by PNS injury due to trauma, disease or exposure to drugs, toxins or viral pathogens. Despite the high regenerative capacity of DRG neurons, sensory recov-ery after PNS injury is often incomplete and severe neuropathic pain may last for years. Although numerous mechanisms of PNS injury have been established, neuropathic pain is refractory to therapy, contributing to the physical and emotional suffering of patients and the enormous economic burden to society.
机标关键词：
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1890-1892 )