MicroRNAs of microglia: wrestling with central nervous system disease
Xiao-Hua Wang
Tian-Long Wang
摘要：Microglia serve as brain-resident myeloid cells that affect cerebral development, ischemia, neurodegen-eration, and neuro-viral infection. MicroRNAs play a key role in central nervous system disease through post-transcriptional regulation. Indeed, evidence shows that microRNAs are one of the most important regulators mediating microglial activation, polarization, and autophagy, and subsequently affecting neuroin-flammation and the outcome of central nervous system disease. In this review, we provide insight into the function of microRNAs, which may be an attractive strategy and influential treatment for microglia-related central nervous system dysfunction. Moreover, we comprehensively describe how microglia fight against cen-tral nervous system disease via multiple functional microRNAs.
机标关键词：
资助基金：the National Natural Science Foundation of China, (No. 81401084)Beijing Municipal Ad-ministration of Hospital Ascent Plan, (No. DFL20150802)Beijing 215 High Level Healthcare Talent Plan Academic Leader, (No. 008-0027)Beijing Municipal Commission of Health and Family Planning, (No. PXM2017_026283_000002)Beijing Mu-nicipal Administration of Hospitals Clinical Medicine Development of Special Funding, (No. ZYLX201706)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 2067-2072 )
英文信息