Memory consolidation during sleep and adult hippocampal neurogenesis
Iyo Koyanagi
Katherine G. Akers
Pablo Vergara
Sakthivel Srinivasan
Takeshi Sakurai
Masanori Sakaguchi
摘要：In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great ef-forts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarify-ing the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review.
机标关键词：
资助基金：This work was partially supported by the MEXT World Premier International Research Center Initiative, CREST JST, MEXT KAKENHI for Scientific Research on Innovative Areas "Microendophenotype"(25116530)"Memory Dynamism"(26115502)JSPS KAKENHI Grants(16K18359)JSPS KAKENHI Grants( 15F15408)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 20-23 )
英文信息