Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus
Francesca Antonelli
Arianna Casciati
Simonetta Pazzaglia
摘要：The morphogen Sonic Hedgehog (Shh) plays a critical role in the development of different tissues, both in invertebrates and vertebrates. Shh mediates its action via a receptor com-plex associating two transmembrane proteins: Patched1 (Ptch1) and Smoothened (Smo). The repression exerted by Ptch1 on Smo is relieved when Shh, the ligand, binds to Ptch1, which leads to a complex signaling cascade involving the transcription factors of the Gli family and finally, to the activation of targeted genes including Ptch1 and Gli them-selves.
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 59-61 )