Combinatorial therapies for spinal cord injury: strategies to induce regeneration
Eduardo D. Gomes
Nuno A. Silva
António J. Salgado
摘要：Spinal cord injury (SCI) is a condition without treatment, mainly characterized by the loss of motor and sensory function below the level of injury. This is accompanied by several complications such as cardiac and respiratory compromise, and often patients present psychological ail-ments associated with the drastic alteration of their nor-mal lifestyle. SCI pathophysiology derives from a massive damage to the spinal cord tissue, which is propagated by secondary events such as inflammation, excitotoxicity among others, that increase neuronal loss. In a later stage, a glial scar composed by reactive astrocytes and a cystic cavity are formed, creating a physical and chemical bar-rier for axonal regrowth. Strategies capable of inducing neuronal regeneration are therefore a fundamental part for a successful recovery of function for these patients.
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资助基金：The authors want to acknowledge the financial support from Prémios Santa Casa Neurociências - Prize Melo e Castro for Spinal Cord Injury Research(MC-04/17)Doctoral fellowship (SFRH/BD/103075/2014)Post- Doctoral fellowship (SFRH/BPD/97701/2013) This work is funded by national funds through FCT under the scope of grant reference TUBITAK/0007/2014 and 3599-PPCDT Project(TE 2020)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 69-71 )