Finding a way to preserve mitochondria: new pathogenic pathways in experimental multiple sclerosis
Andrea Mancini
Lorenzo Gaetani
Lucia Gentili
Massimiliano Di Filippo
摘要：Multiple sclerosis (MS) is a chronic disorder affecting central ner-vous system (CNS) in which inflammatory and neuro-degenerative features coexist since the earlier phases of the disease (Reich et al., 2018). During last years, attention has been directed toward the possible pathogenic pathways linking these two different features characterizing MS, in order to acquire a better understanding of the disease pathogenesis and to design new disease modifying therapies. Currently available therapies for MS are primarily aimed at modulating the immune system and are successfully used to reduce the risk of new inflammatory CNS lesions but show little or no efficacy in counteracting irreversible disease progression over time. Among the possible mechanism linking neuroinflamma-tion and neuronal loss, attention has been focused on the possible dysfunction of neuronal mitochondria during inflammatory CNS processes, since an impaired neuronal energetic support seems to represent a key event in the pathogenesis of neuro-axonal degener-ation (Campbell et al., 2014).
机标关键词：
资助基金：MDF received support by Fondazione Italiana Sclerosi Multipla (FISM) (project code 2013/R/12)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 77-78 )