Adenosine triphosphate maintenance by branched chain amino acids as a novel neuroprotective strategy for retinal neurodegenerative diseases
Tomoko Hasegawa
Hanako Ohashi Ikeda
摘要：Retinal neuronal cell death is caused in many incurable eye diseases such as retinitis pigmentosa (RP) and glau-coma, which are leading causes of adult blindness. In RP, progressive loss of photoreceptor cells leads to visual dis-turbance. No established treatments are available to date for this condition, although potential treatments, includ-ing regenerative medicine, gene therapy, and neurotropic factor therapy are being investigated. In glaucoma, retinal ganglion cell death leads to visual disturbance. Although intraocular pressure reduction is the only established treatment to slow the loss of visual function in glaucoma, there are a fair number of cases where visual impairment progresses despite intraocular pressure being maintained within the normal range. Therapeutic strategies to pre-vent neuronal cell death are being pursued.
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资助基金：This research was supported by the Japan Agency for Med-ical Research and Development (to HOI).Kyoto University has applied for patents related to this study(PCT/JP2016/053914)This research was supported by the Japan Agency for Med-ical Research and Development ( 2016-023044)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 82-84 )